Consensus | By Banning AP, Lassen JF, Burzotta F et al.
The European Bifurcation Club recommends an approach to a bifurcation stenosis which involves careful assessment, planning and a sequential provisional approach. In the minority of lesions where two stents are required, careful deployment and optimal expansion are essential to achieve a long-term result.
Pulmonary Artery Denervation Using Catheter based Ultrasonic Energy
Original Research | By Rothman A, Jonas M, Castel D et al.
AIMS - Pulmonary arterial hypertension is a devastating disease characterized by pulmonary vascular remodelling and right heart failure. Radio-frequency pulmonary artery denervation (PDN) improves pulmonary hemodynamics in pre-clinical and early clinical studies, however denervation depth is limited. High-frequency non-focused ultrasound can deliver energy to the vessel adventitia, sparing the intima and media. We therefore investigated t...
Immunotherapy of Endothelin-1 Receptor Type A for Pulmonary Arterial Hypertension
Original Research | By Dai Y, Chen X, Zhou Z et al.
BACKGROUND - Pulmonary arterial hypertension (PAH) is a chronic fatal disease. The treatment of PAH is less than ideal and the control is far from satisfactory worldwide. Vaccination provides a promising approach for treatment of PAH. OBJECTIVES - This study sought to find a vaccine against endothelin-1 (ET-1) receptor type A (ETAR) for treating PAH. METHODS - ...
Active and Passive Vaccination for Pulmonary Arterial Hypertension: A Novel Therapeutic Paradigm
Editorial | By Prediman K. Shah
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Original Research | By W Yu, JY Huang, SX Tu et al.
AIMS - A novel method for computation of fractional flow reserve (FFR) from optical coherence tomography (OCT) was developed recently. This study aimed to evaluate the diagnostic accuracy of a new OCT-based FFR (OFR) computational approach, using wire-based FFR as the reference standard. METHODS AND RESULTS - Patients who underwent both OCT and FFR prior to intervention were analysed. The lum...
Original Research | By Murphy SA, Pedersen TR, Gaciong ZA et al.
IMPORTANCE- The PCSK9 inhibitor evolocumab reduced low-density lipoprotein cholesterol and first cardiovascular events in the Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk (FOURIER) trial, but patients remain at high risk of recurrent cardiovascular events. OBJECTIVE - To evaluate the effect of evolocumab on total cardiovascular events, g...
Original Research | By Joyce LC, Baber U, Mehran R et al.
OBJECTIVES- The aim of this study was to examine the association between dual-antiplatelet therapy (DAPT) cessation and cardiovascular risk after percutaneous coronary intervention in relation to age. BACKGROUND - Examination of outcomes by age after percutaneous coronary intervention is relevant given the aging population. METHODS- Two-year clinical outcomes, incidence,...
Editorial | By W Sumaya, RF Storey.
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Review Article | By Maznyczka AM, Oldroyd KG, Berry C et al.
The goal of reperfusion therapies in ST-segment elevation myocardial infarction has evolved to include effective reperfusion of the microcirculation subtended by the culprit epicardial coronary artery. The index of microcirculatory resistance is measured using a pressure- and temperature-sensing coronary guidewire and quantifies microvascular dysfunction. The index of microcirculatory resistance is an independent predictor of microvascu...