2-Year Outcomes After Stenting of Lipid-Rich and Nonrich Coronary Plaques
Original Research | By MHwa Yamamoto, A Maehara, GW Stone et al.
BACKGROUND- Autopsy studies suggest that implanting stents in lipid-rich plaque (LRP) may be associated with adverse outcomes. OBJECTIVES- The purpose of this study was to evaluate the association between LRP detected by near-infrared spectroscopy (NIRS) and clinical outcomes in patients with coronary artery disease treated with contemporary drug-eluting stents. METHODS...
Original Research | By G Mendieta, S Ben-Aicha, M Gutiérrez et al.
BACKGROUND - Beyond lipid-lowering, statins exert cardioprotective effects. High-dose statin treatment seems to reduce cardiovascular complications in high-risk patients. The ideal timing and administration regime remain unknown. OBJECTIVES - This study compared the cardioprotective effects of intravenous statin administration during myocardial infarction (MI) with oral administratio...
Polymer-based or Polymer-free Stents in Patients at High Bleeding Risk
Original Research | By S Windecker, A Latib, the ONYX ONE Investigators et al.
BACKGROUND - Polymer-free drug-coated stents provide superior clinical outcomes to bare-metal stents in patients at high bleeding risk who undergo percutaneous coronary intervention (PCI) and are treated with 1 month of dual antiplatelet therapy. Data on the use of polymer-based drug-eluting stents, as compared with polymer-free drug-coated stents, in such patients are limited. METHODS - In an interna...
Clinical Trial | By YJ Youn, J-W Lee, J Yoon et al.
BACKGROUND - There is limited data comparing the Xience everolimus-eluting stent (EES) and the Resolute zotarolimus-eluting stent (ZES) with the BioMatrix biolimus-eluting stent (BES). METHODS - This open-label, randomized, noninferiority trial enrolled all-comer patients to be randomly treated with either BES, EES, or ZES in a 1:1:1 ratio in 15 centers across South Korea. The primar...
Clopidogrel Pharmacogenetics: State-of-the-Art Review and the TAILOR-PCI Study
Review Article | By NL Pereira, CS Rihal, DYF So et al.
Common genetic variation in CYP2C19 (cytochrome P450, family 2, subfamily C, polypeptide 19) *2 and *3 alleles leads to a loss of functional protein, and carriers of these loss-of-function alleles when treated with clopidogrel have significantly reduced clopidogrel active metabolite levels and high on-treatment platelet reactivity resulting in increased risk of major adverse cardiovascular events, especially after percutaneous ...
Genotype-Guided Strategy for Oral P2Y12 Inhibitors
March 28, 2020 — The TAILOR-PCI trial that used genetic testing to guide which antiplatelet medication was given to patients following percutaneous coronary intervention (PCI) did not meet its primary endpoint of cutting in half the incidence of serious adverse cardiovascular events. This included heart attack and stroke, in the year following the procedure. However, researchers reported a 34 percent reduction in these adverse events at one ye...
Clinical Trial | By B Pieske, MJ Patel, VICTORIA Study Group et al.
Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction
Clinical Trial | By PW Armstrong, B Pieske, the VICTORIA Study Group
BACKGROUND - The effect of vericiguat, a novel oral soluble guanylate cyclase stimulator, in patients with heart failure and reduced ejection fraction who had recently been hospitalized or had received intravenous diuretic therapy is unclear. METHODS - In this phase 3, randomized, double-blind, placebo-controlled trial, we assigned 5050 patients with chronic heart failure (New York Heart Association clas...