Association Between Depressive Symptoms and Incident Cardiovascular Diseases
Review Article | By EL Harshfield, L Pennells, Emerging Risk Factors Collaboration.
IMPORTANCE - It is uncertain whether depressive symptoms are independently associated with subsequent risk of cardiovascular diseases (CVDs). OBJECTIVE - To characterize the association between depressive symptoms and CVD incidence across the spectrum of lower mood. DESIGN, SETTING, AND PARTICIPANTS - A pooled analysis of individual-part...
Original Research | By D Han, B Tamarappoo, E Klein et al.
AIMS - Recovery of left ventricular ejection fraction (LVEF) after aortic valve replacement has prognostic importance in patients with aortic stenosis (AS). The mechanism by which myocardial fibrosis impacts LVEF recovery in AS is not well characterized. We sought to evaluate the predictive value of extracellular volume fraction (ECV) quantified by cardiac CT angiography (CTA) for LVEF recovery in patients with AS after transcathe...
Initial experience with percutaneous mitral valve repair in patients with cardiac amyloidosis
Original Research | By MJ Volz, ST Pleger, A Weber et al.
BACKGROUND - Percutaneous mitral valve repair (PMVR) is a therapeutic option for severe mitral regurgitation (MR) in patients with heart failure due to differential etiologies. However, only little is known about the safety and efficacy of this procedure in patients with amyloid cardiomyopathy. METHODS - Five Patients with cardiac amyloidosis and moderate to severe or severe MR...
Post-Stroke Cardiovascular Complications and Neurogenic Cardiac Injury: JACC State-of-the-Art Review
Pathophysiology, diagnosis and new therapeutic approaches for ischemic mitral regurgitation
Review Article | By S Hadjadj, O Marsit, J-M Paradis et al.
Ischemic mitral regurgitation is a valvular complication frequently seen in patients with coronary artery disease and associated with increased mortality and morbidity. Ischemic mitral regurgitation has a complex, heterogeneous and still incompletely understood pathophysiology involving both the mitral valve and the left ventricle. The occurrence of valve regurgitation in patients with ischemic cardiomyopathy will in return accelerate left ventricular rem...
Original Research | By K Vaidya , BJ Cochran, S Patel et al.
Review Article | By F Yarmohammadi, R Rezaee, AW Haye et al.
Doxorubicin (DOX) is a chemotherapeutic agent with marked, dose-dependent cardiotoxicity that leads to tachycardia, atrial and ventricular arrhythmia, and irreversible heart failure. Induction of the endoplasmic reticulum (ER) which plays a major role in protein folding and calcium homeostasis was reported as a key contributor to cardiac complications of DOX. This article reviews several chemical compounds that have been shown to regul...