Clinical Trial | By D Collison, M Didagelos, M Aetesam-Ur-Rahman et al.
Guideline | By TM Sundt; H Jneid et al.
The continued evolution of transcatheter aortic valve implantation (TAVI) technology and the results of multiple randomized clinical trials (RCTs) have firmly established this approach as an alternative to surgical aortic valve replacement (SAVR) in the treatment of aortic stenosis in all risk groups. Deciding on TAVI or SAVR depends on patient-specific factors, including technical, procedure-specific contraindications and the balance b...
Original Research | By DH Kim, A Pawar, JJ Gagne et al.
BACKGROUND - The role of differing levels of frailty in the choice of oral anticoagulants for older adults with atrial fibrillation (AF) is unclear. OBJECTIVE - To examine the outcomes of direct oral anticoagulants (DOACs) versus warfarin by frailty levels. DESIGN - 1:1 propensity score–matched analysis of Medicare data, 2010 to 2017. SETTING - Community. PATIENTS - Medicare beneficiaries w...
Original Research | By C Brouessard, AS Bobet, M Mathieu et al.
Potential protective mechanisms of green tea polyphenol EGCG against COVID-19
Original Research | By Y Zhang, B Wernly, ZCh Zhou et al.
BACKGROUND - The world is in the midst of the COVID-19 pandemic. In this comprehensive review, we discuss the potential protective effects of (−)-epigallocatechin-3-gallate (EGCG), a major constituent of green tea, against COVID-19. SCOPE AND APPROACH - Information from literature of clinical symptoms and molecular pathology of COVID-19 as well as relevant publications in which EGCG show...
Clinical Trial | By D Hildick-Smith, M Egred, Y Louvard et al.
Potential Mechanisms of In-stent Neointimal Atherosclerotic Plaque Formation
Review Article | By DM Zhang, SL Chen.
Percutaneous coronary intervention has become the main revascularization strategy for coronary artery disease. Compared with early percutaneous coronary angioplasty and the extensive clinical application of bare metal stents, drug-eluting stents can significantly reduce the stenosis caused by the elastic retraction of plaque and neoatherosclerosis (NA), but there is still a high incidence of in-stent restenosis (ISR), which restricts the clinica...
Original Research | By S Garcia, RJ Cubeddu, RT Hahn et al.
OBJECTIVES - The aim of this study was to compare 5-year cardiovascular, renal, and bioprosthetic valve durability outcomes in patients with severe aortic stenosis (AS) and chronic kidney disease (CKD) undergoing transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR). BACKGROUND - Patients with severe AS and CKD undergoing TAVR or SAVR are a challenging...