Original Research | By ZQ Zhao, XB Zhang, HY Zhang et al.
Thrombotic cardio-cerebrovascular diseases seriously threaten human health. Currently, conventional thrombolytic treatments are challenged by the low utilization, inferior thrombus penetration, and high off-target bleeding risks of most thrombolytic drugs, resulting in unsatisfactory treatment outcomes. Herein, it is proposed that these challenges can be overcome by precisely integrating the conventional thrombolytic strategy wi...
Original Research | By L Marroquin, G Tirado-Conte, R Pracoń et al.
Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk
Clinical Trial | By M Valgimigli, E Frigoli, the MASTER DAPT Investigators et al.
BACKGROUND - The appropriate duration of dual antiplatelet therapy in patients at high risk for bleeding after the implantation of a drug-eluting coronary stent remains unclear. METHODS - One month after they had undergone implantation of a biodegradable-polymer sirolimus-eluting coronary stent, we randomly assigned patients at high bleeding risk to discontinue dual antiplatelet therapy immediately (abbreviated t...
Macrophage MST1/2 Disruption Impairs Post-Infarction Cardiac Repair via LTB4
Fractional Flow Reserve–Guided PCI as Compared with Coronary Bypass Surgery
Clinical Trial | By WF Fearon, FM Zimmermann, the FAME 3 Investigators et al.
BACKGROUND - Patients with three-vessel coronary artery disease have been found to have better outcomes with coronary-artery bypass grafting (CABG) than with percutaneous coronary intervention (PCI), but studies in which PCI is guided by measurement of fractional flow reserve (FFR) have been lacking. METHODS - In this multicenter, international, noninferiority trial, patients with three-vessel coronary ...
Original Research | By E Oosterwerff, A Adiyaman, A Elvan et al.
BACKGROUND - The subcutaneous cardioverter-defibrillator (S-ICD) continues to be preferentially used in relatively young patients, with less advanced heart disease. OBJECTIVE - We, therefore, studied the short and long-term efficacy and safety of the S-ICD in subgroups of patients, which are underreported at present. METHODS - A total of 218 patients between Nov...
Clinical Trial | By SD Gao, WJ Ma, MY Yu
The association between elevated lipoprotein(a) [Lp(a)] and poor outcomes in coronary artery disease (CAD) has been addressed for decades. However, little is known about the prognostic value of Lp(a) in patients with myocardial infarction with nonobstructive coronary arteries (MINOCA). A total of 1179 patients with MINOCA were enrolled and divided into low, medium, and high Lp(a) groups based on the cut...