Ablation Versus Drug Therapy for Atrial Fibrillation in Heart Failure Results From the CABANA Trial
Clinical Trial | By DL Packer, JP Piccini, CABANA Investigators et al.
Original Research | By A Nakajima , T Sugiyama , M Araki et al.
BACKGROUND - Vascular inflammation plays a key role in plaque rupture, while the role of inflammation in plaque erosion remains less well defined. Peri-coronary adipose tissue (PCAT) attenuation determined by computed tomography has emerged as a marker specific for coronary artery inflammation. OBJECTIVES - To compare the level of coronary inflammation between plaque rupture and plaque erosion usin...
Original Research | By P Petsophonsakul, M Burgmaier, B Willems et al.
Clinical Trial | By IJ Choi, SM Lim, K Chang et al.
OBJECTIVES - The aim of this study was to examine the impact of intravascular ultrasound (IVUS)–guided percutaneous coronary intervention (PCI) on long-term clinical outcomes in patients with acute myocardial infarction (AMI). BACKGROUND - IVUS-guided PCI has been associated with improved cardiovascular outcomes. However, the beneficial effect of IVUS-guided PCI in patients with AMI in th...
Original Research | By Y Zhang, Y Qi, JJ Li, WJ He et al.
AIMS - Despite numerous reports documenting an important role of hypertension in the development of atrial fibrillation (AF), the detailed mechanism underlying the pathological process remains incompletely understood. Here, we aim to test the hypothesis that diastolic sarcoplasmic reticulum (SR) Ca2+leak in atrial myocytes, induced by mechanical stretch due to elevated pressure in the left atrium (LA), plays an essential ro...
Clinical Trial | By B Xu, SX T, L Song et al.
BACKGROUND - Compared with visual angiographic assessment, pressure wire-based physiological measurement more accurately identifies flow-limiting lesions in patients with coronary artery disease. Nonetheless, angiography remains the most widely used method to guide percutaneous coronary intervention (PCI). In FAVOR III China, we aimed to establish whether clinical outcomes might be improved by lesion selection for PCI using t...
Original Research | By P Osmancik, D Herman,VY Reddy et al.
BACKGROUND - The PRAGUE-17 trial demonstrated that left atrial appendage closure (LAAC) was non-inferior to non-warfarin oral anticoagulants (NOAC) for preventing major neurological, cardiovascular or bleeding events in high-risk patients with atrial fibrillation (AF). OBJECTIVE - To assess the pre-specified long-term (4-year) outcomes in PRAGUE-17. METHODS - P...
Review Article | By MS Sabatine, BA Bergmark, SA Murphy et al.
BACKGROUND - The optimal revascularisation strategy for patients with left main coronary artery disease is uncertain. We therefore aimed to evaluate long-term outcomes for patients treated with percutaneous coronary intervention (PCI) with drug-eluting stents versus coronary artery bypass grafting (CABG). METHODS - In this individual patient data meta-analysis, we searched MEDLINE, Embase, and the...
Acute Aortic Syndrome Revisited: JACC State-of-the-Art Review
Review Article | By I Vilacosta, JAS Román , R di Bartolomeo et al.
The purpose of this paper is to describe all available evidence on the distinctive features of a group of 4 life-threatening acute aortic pathologies gathered under the name of acute aortic syndrome (AAS). The epidemiology, diagnostic strategy, and management of these patients has been updated. The authors propose a new and simple diagnostic algorithm to support clinical decision making in cases of suspected AAS, thereby minimizing diagnosti...