Predictors of Left Main Coronary Artery Disease in the ISCHEMIA Trial
Original Research | By R Senior , HR Reynolds , JK Min et al.
BACKGROUND - Detection of ≥50% diameter stenosis left main coronary artery disease (LMD) has prognostic and therapeutic implications. Noninvasive stress imaging or an exercise tolerance test (ETT) are the most common methods to detect obstructive coronary artery disease, though stress test markers of LMD remain ill-defined. OBJECTIVES - The authors sought to identify markers of LMD as detected o...
Original Research | By LC Schröder, A Holkeri, A Eranti et al.
Original Research | By A Mehta, N Vasquez, CR Ayers et al.
BACKGROUND - Elevated lipoprotein(a) [Lp(a)] and coronary artery calcium (CAC) score are individually associated with increased atherosclerotic cardiovascular disease (ASCVD) risk but have not been studied in combination. OBJECTIVES - This study sought to investigate the independent and joint association of Lp(a) and CAC with ASCVD risk. METHODS - Plasma Lp(a) and...
2-Year Outcomes After Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients
Clinical Trial | By JK Forrest, GM Deeb, SJ Yakubov et al.
BACKGROUND - The Evolut Low Risk Trial (Medtronic Evolut Transcatheter Aortic Valve Replacement in Low Risk Patients) showed that transcatheter aortic valve replacement (TAVR) with a supra-annular, self-expanding valve was noninferior to surgery for the primary endpoint of all-cause mortality or disabling stroke at 2 years. This finding was based on a Bayesian analysis performed after 850 patients had reach...
Clinical Trial | By M Götberg, K Berntorp, R Rylance et al.
BACKGROUND - Instantaneous wave-free ratio (iFR) is a coronary physiology index used to assess the severity of coronary artery stenosis to guide revascularization. iFR has previously demonstrated noninferior short-term outcome compared to fractional flow reserve (FFR), but data on longer-term outcome have been lacking. OBJECTIVES - The purpose of this study was to investigate the prespecified 5-year follow-up of...
Original Research | By GM Deeb, MJ Reardon, B Ramlawi et al.
OBJECTIVES - The aim of this study was to compare 1-year outcomes after transcatheter aortic valve replacement (TAVR) in low surgical risk patients with bicuspid aortic stenosis to patients with tricuspid aortic stenosis. BACKGROUND - The pivotal TAVR trials excluded patients with bicuspid aortic valves. The Low Risk Bicuspid Study 30-day primary endpoint of death or disabling stroke was 1.3%. ...
Effect of SGLT2-Inhibitors on Epicardial Adipose Tissue: A Meta-Analysis
Review Article | By W Masson, A Lavalle-Cobo, JP Nogueira et al.
Original Research | By NR Pugliese, F Paneni, M Mazzola et al.
AIMS - We evaluated the impact of echocardiographic epicardial adipose tissue (EAT) on cardiovascular haemodynamics, metabolic profile and prognosis in heart failure (HF) using combined cardiopulmonary-echocardiography exercise stress. METHODS AND RESULTS - We analysed EAT thickness of HF patients with reduced (HFrEF, n = 205) and preserved (HFpEF, n = 188) ejection fraction, including 44 contro...