Mathematical modelling of endovascular drug delivery: balloons versus stents
Clinical Trial | By J Delgado-Lista, J Lopez-Miranda, CORDIOPREV Investigators et al.
BACKGROUND - Mediterranean and low-fat diets are effective in the primary prevention of cardiovascular disease. We did a long-term randomised trial to compare the effects of these two diets in secondary prevention of cardiovascular disease. METHODS - The CORDIOPREV study was a single-centre, randomised clinical trial done at the Reina Sofia University Hospital in Córdoba, Spain. Patients wit...
Circadian Cadence and NR1D1 Tune Cardiovascular Disease
Original Research | By YC Zhao , XY Lu , F W et al.
BACKGROUND - Shift work is associated with increased risk of acute myocardial infarction (AMI) and worsened prognosis. However, the mechanisms linking shift work and worsened prognosis in AMI remain unclear. OBJECTIVES - This study sought to investigate the impact of shift work on reperfusion injury, a major determinant of clinical outcomes in AMI. METHODS - Study patient data were...
Review Article | By DJ van Ginkel, WL Bor, E Fabris et al.
Thromboembolic and bleeding complications negatively impact recovery and survival after transcatheter aortic valve implantation (TAVI). Particularly, there is a considerable risk of ischaemic stroke and vascular access related bleeding, as well as spontaneous gastro-intestinal bleeding. Therefore, benefit and harm of antithrombotic therapy should be carefully balanced. This review summarizes current evidence on peri- and post-procedural a...
Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium
Original Research | By S Gencer, Y Döring, EPC van der Vorst et al.
Prognostic implication of lipidomics in patients with coronary total occlusion undergoing PCI
Original Research | By Y Zhou, XD Wang, JY Qian et al.
BACKGROUND - Predictors of prognosis in patients with coronary chronic total occlusion (CTO) undergoing elective percutaneous coronary intervention (PCI) have remained lacking. Lipidomic profiling enable researchers to associated lipid species with disease progression and may improve the prediction of cardiovascular events. METHODS- In the present study, 781 lipids were measured by targeted lipidomic ...
Original Research | By J Kan, SL Chen, DEFINITION II Investigators et al.
2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension
Guideline | By ESC/ERS Scientific Document Groupnt of pulmonary hypertension
Pulmonary Artery Denervation for Pulmonary Arterial Hypertension: A Sham-Controlled Randomized Trial
Original Research | By H Zhang , YY Wei , SL Chen et al.
BACKGROUND - WHO Group I pulmonary arterial hypertension (PAH) is a progressive, debilitating disease. Previous observational studies have demonstrated that pulmonary artery denervation (PADN) reduces pulmonary arterial pressures in PAH. However, the safety and effectiveness of PADN have not been established in a randomized trial. OBJECTIVES - We aimed to determine the treatment effects of PADN in...