Original Research | By I Ceponiene, R Nakanishi, K Osawa et al.
OBJECTIVES - The aim of this study was to determine whether coronary artery calcium (CAC) progression was associated with coronary plaque progression on coronary computed tomographic angiography. BACKGROUND - CAC progression and coronary plaque characteristics are associated with incident coronary heart disease. However, natural history of coronary atherosclerosis has not been well described to date,...
Original Research | By Nakanishi R, Ceponiene I, Osawa K et al.
BACKGROUND AND AIMS - We aimed at investigating whether diabetes is associated with progression in coronary plaque components. METHODS - We identified 142 study subjects undergoing serial coronary computed tomography angiography. The resulting propensity score was applied 1:1 to match diabetic patients to non-diabetic patients for clinical risk factors, prior coronary stenting, coronary arterycalcium (CAC) ...
Impact of Statins on Cardiovascular Outcomes Following Coronary Artery Calcium Scoring
Original Research | By JD Mitchell, N Fergestrom, BF Gage et al.
BACKGROUND - Compared with traditional risk factors, coronary artery calcium (CAC) scores improve prognostic accuracy for atherosclerotic cardiovascular disease (ASCVD) outcomes. However, the relative impact of statins on ASCVD outcomes stratified by CAC scores is unknown. OBJECTIVES - The authors sought to determine whether CAC can identify patients most likely to benefit from ...
Review Article | By Karlson BW, Palmer MK, Nicholls SJ et al.
Elevated triglyceride (TG) levels are associated with increased cardiovascular disease risk. In patients with mild-to-moderate hypertriglyceridemia, defined by the European Atherosclerosis Society Consensus Panel as a TG level of 177 to 885 mg/dl (2.0 to 10.0 mmol/L), low-density lipoprotein cholesterol (LDL-C) reduction remains the primary treatment goal. Using data from the indiVidual patient meta-analysis Of stat...
Genetics and Causality of Triglyceride-Rich Lipoproteins in Atherosclerotic Cardiovascular Disease
Review Article | By Rosenson RS, Davidson MH, Hirsh BJ et al.
Review Article | By Zhang L, Zhang S, Ge J et al.
BACKGROUND - The VOYAGER meta-analysis reported on the low-density lipoprotein cholesterol (LDL-C)-lowering effect of commonly used statins in Caucasian subjects. As there is limited literature available on the efficacy of statins in Asian populations, the current meta-analysis compared the effects of rosuvastatin and atorvastatin on LDL-C levels in an East Asian population. METHODS - T...
Revascularization of left main coronary artery
Review Article | By Baydoun H, Jabbar A, Nakhle A et al.
Highlights - CABG is still the preferred way to treat patients with unprotected left main disease (UPLMD). - PCI is a reasonable approach mainly in patients with high surgical risk and non-complex anatomy (Syntax score <33). - IVUS-guided PCI is associated with lower risks of all-cause death, cardiac death, T...
Left main coronary angioplasty: early and late results of 127 acute and elective procedures
Clinical Trial | By O'Keefe JH Jr, Hartzler GO, Rutherford BD
The results of 127 left main (LM) coronary angioplasties were reviewed to assess short- and long-term effectiveness. Three major subgroups were considered: (1) elective "protected" (defined as the presence of a patent bypass graft to the left coronary circulation) patients (n = 84); (2) elective "unprotected" patients (n = 33); and (3) acute patients, in whom LM coronary angioplasty was performed in the setting of an acute myocardial infarc...
Unprotected Left Main Disease: Indications and Optimal Strategies for Percutaneous Intervention
Review Article | By Li J, Patel SM, Parikh SA et al.
Although the incidence of leftmain (LM) coronary artery disease is relatively low in patients undergoing routine angiography, it is a common presentation in patients with acute coronary syndromes. With the current interventional tools and techniques, percutaneous intervention for LM disease has become a viable alternative to the traditional coronary artery bypass grafting. Factors that contribute to the success and appropriateness of p...