Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia
Clinical Trial | By Bhatt DL, Steg PG, REDUCE-IT Investigators.
BACKGROUND - Patients with elevated triglyceride levels are at increased risk for ischemic events. Icosapent ethyl, a highly purified eicosapentaenoic acid ethyl ester, lowers triglyceride levels, but data are needed to determine its effects on ischemic events. METHODS - We performed a multicenter, randomized, double-blind, placebo-controlled trial involving patients with established cardiovascular diseas...
Original Research | By Diamond J, Madhavan MV, Stone GW et al.
OBJECTIVES - The aim of this study was to determine whether high-risk patients with left main coronary artery disease (LMCAD) and prior cerebrovascular disease (CEVD) preferentially benefit from revascularization by percutaneous coronary intervention (PCI) compared with coronary artery bypass grafting (CABG). BACKGROUND - Patients with known CEVD requiring revascularization are often referred to ...
Original Research | By Chen S, Redfors B, Stone GW et al.
OBJECTIVES - There is a paucity of data on the effect of baseline lipid-lowering therapy (LLT) in patients undergoing revascularization for left main (LM) coronary artery disease (CAD). We compared outcomes for patients with LMCAD randomized to percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) according to the presence of baseline LLT in the EXCEL trial. PATIE...
Outcomes Among Patients Undergoing Distal Left Main Percutaneous Coronary Intervention
Clinical Trial | By Kandzari DE, Gershlick AH, Stone GW et al.
BACKGROUND - Distal left main (LM) coronary artery bifurcation disease increases percutaneous coronary intervention (PCI) procedural complexity and is associated with worse outcomes than isolated ostial/shaft disease. The optimal treatment strategy for distal LM disease is undetermined. We sought to determine whether outcomes after PCI of LM distal bifurcation lesions are influenced by treatment with a provisional 1-stent...
Review Article | By Kosmidou I, Stone GW.
PURPOSE OF REVIEW - To provide an up-to-date review of recent trials examining the incidence and prognostic impact of new-onset atrial fibrillation (NOAF) following percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) for left main coronary artery disease (LMCAD) and the impact of postprocedural NOAF compared to nonsurgical atrial fibrillation. RECENT FINDIN...
Original Research | By Chen S, Redfors B, Stone GW et al.
AIMS - We sought to compare clinical outcomes and procedural characteristics with transradial access (TRA) versus transfemoral access (TFA) in patients who were treated with PCI for left main (LM) coronary artery disease. METHODS AND RESULT - The EXCEL trial was a prospective, international, open-label, multicentre trial that randomised 1,905 patients with LM disease and SYNT...
Left Main Revascularization With PCI or CABG in Patients With Chronic Kidney Disease: EXCEL Trial
Original Research | By Giustino G, Mehran R, Stone GW et al.
BACKGROUND - The optimal revascularization strategy for patients with left main coronary artery disease (LMCAD) and chronic kidney disease (CKD) remains unclear. OBJECTIVES - This study investigated the comparative effectiveness of percutaneous coronary intervention (PCI) versus coronary artery bypass graft (CABG) surgery in patients with LMCAD and low or intermediate anatomical complexity...
Original Research | By Writing Group Members, JU Doherty, S Kort, R Mehran et al.
Differential Impact of Heart Failure With Reduced Ejection Fraction on Men and Women
Angiotensin–neprilysin inhibition versus enalapril in heart failure
Clinical Trial | By McMurray JJ, Packer M, PARADIGM-HF Investigators and Committees.