Original Research | By Nomura T, Kikai M, Hori Y et al.
In practical settings of percutaneous coronary intervention (PCI), we sometimes encounter difficulty in introducing a guidewire (GW) to the markedly angulated side branch (SB), and the reverse wire technique is considered as a last resort to overcome such a situation. We analyzed 12 cases that underwent PCI with dual-lumen microcatheter-facilitated reverse wire technique between January 2013 and July 2016. We retrospectively...
Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events in the ODYSSEY OUTCOMES Trial
Clinical Trial | By M Szarek, HD White, PH Steg, ODYSSEY OUTCOMES Committees and Investigators.
Effect of Aspirin on All-Cause Mortality in the Healthy Elderly
Clinical Trial | By McNeil JJ, Nelson MR, ASPREE Investigator Group.
BACKGROUND - In the primary analysis of the Aspirin in Reducing Events in the Elderly (ASPREE) trial, now published in the Journal, we report that the daily use of aspirin did not provide a benefit with regard to the primary end point of disability-free survival among older adults. A numerically higher rate of the secondary end point of death from any cause was observed with aspirin than with placebo. METHOD...
Longitudinal Change in Galectin-3 and Incident Cardiovascular Outcomes
Original Research | By A Ghorbani, V Bhambhani, RH Christenson et al.
BACKGROUND - Galectin-3 (Gal-3) has been associated with heart failure (HF) and poor cardiovascular outcomes. However, the effect of longitudinal changes in Gal-3 on clinical outcomes remains unclear. OBJECTIVES - The authors sought to study clinical determinants of change in Gal-3 among community-dwelling individuals. Further, they sought to examine the role of serial Gal-3 measurements in ...
Original Research | By Wadhera RK, Joynt Maddox KE, Wasfy JH et al.
Original Research | By Huang X, Redfors B, Stone GW et al.
OBJECTIVES - Percutaneous coronary intervention (PCI) is often favoured over coronary artery bypass grafting (CABG) surgery for revascularization in patients with chronic obstructive pulmonary disease (COPD). We studied whether COPD affected clinical outcomes according to revascularization in the Evaluation of XIENCE Versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization (EXCEL) tria...
Original Research | By Siasos G, Tsigkou V, Stone PH et al.
PURPOSE OF REVIEW - The natural history of coronary atherosclerosis is complex and atherosclerotic plaques exhibit large morphologic and functional variability within the same individual as well as over time. The purpose of this article is to review the role of blood flow patterns and shear stress on the development of microvascular and epicardial endothelial dysfunction and atherosclerosis progression. REC...
Original Research | By Torii R, Stettler R, Bourantas CV et al.
OBJECTIVE - To examine the implications of endothelial shear stress (ESS) distribution in the formation of neoatherosclerotic lesions. METHODS - Thirty six patients with neoatherosclerotic lesions on optical coherence tomography (OCT) were included in this study. The OCT data were used to reconstruct coronary anatomy. Blood flow simulation was performed in the models reconstructed from the stent borders...
Editorial | By Stone PH, Coskun AU, Croce KJ.
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